Both clubs are unbeaten in the league but although Runcorn have won all eight of their NWCL premier division games, they lost 4-0 at Droylsden last week in the FA Cup.
North End, four points behind, have yet to lose in any competition. Manager Chris Willcock said: "We're really looking forward to the challenge."
Keith Briggs once again has the luxury of picking from a fully fit squad as Stalybridge Celtic prepare to take on Leamington at Bower Fold, but there is competition for places in midfield thanks to the arrival of Wade Joyce.
The former Barnsley and St Johnstone youngster made his debut as a second-half substitute in the 1-1 draw at Boston last weekend and could be pushing for a starting role as Celtic look to build on their promising start to the season.
Furry mascots will be taking part in an interval mascot derby in front of a crowd the Bridge board are hoping will be swelled by those taking advantage of the various discounts the club is offering on Non-League Day.
Hyde go to Gloucester City with a fully-fit squad. Manager Scott McNiven - not to say the fans - must be hoping the side can build on the enterprising display against Tamworth and notch a first win of the season.
In the Evo-stik NPL premier division, unbeaten Curzon Ashton will once again be without Matty Warburton as they prepare to face Rushall Olympic at Tameside Stadium. The striker has a thigh strain and is likely to be out a further week.
Sam Walker misses the match with a damaged hamstring and may not return until the end of the month. Ryan Brook may also be unavailable as his wife is about to give birth. But Simon Woodward can play after recovering from a groin strain.
Paul Phillips and Steve Halford have a fully fit squad to choose from as Ashton United travel to Grantham.
It's the same story for Droylsden in the NPL first division north who will be home to Darlington. However, Luke Horrocks and the popular Sefton Gonzales have left the Butchers Arms. Gonzales has joined Clitheroe.
Charlie Anderson, Andy Brown, Dean Warburton and Ollie Devenney all sustained knocks in Mossley's FA Cup replay with Burscough in midweek. None of them was able to train last night.
Mike Fish, Steve Foster, Liam Higginbotham and James Blair remain sidelined.