The Tigers have not been in the first round proper for 20 years and since the turn of the century their record has been poor, even over the last two seasons when as members of the Conference premier they were exempt to the fourth qualifying round.
Hyde are the senior side tomorrow and will be going into the tie on the back of two victories in which they have scored 13 goals. However, manager Scott McNiven is taking nothing for granted.
"It's going to be tough. I know Marine very well and I know they'll be well organised. At the end of the day we'll be facing 11 Scousers and they never give up. They have an appetite for football and they'll want to come to Ewen Fields and show how good they are," he commented.
McNiven has no injury problems but Adam Blakeman, who scored with a spectacular free kick against Lowestoft, and Adam Thurston, both miss out through suspension.
Stalybridge Celtic travel to Northern League first division side Shildon looking to arrest a slump that has seen them win only once on their travels in the whole of 2014.
Midfielder Matty Mainwaring returns to the squad after recovering from a knee injury but manager Keith Briggs could well ring the changes after being disappointed by his team's second-half performance in the 2-1 defeat at Gainsborough Trinity last week.
Defender Harley Wigley could come in for his first senior start and there might be a return to the starting line-up for wide man Aidan Chippendale.
John Flanagan faces a defensive crisis as Curzon Ashton prepare to take on Scarborough Athletic of the Evo-stik first division north at the Tameside Stadium.
Simon Woodford and Jonathan Hunt are ruled out with a calf strain and ankle ligaments respectively. Darren Thornton is suspended and Andy Watson is on compassionate leave because of a family illness.
Flanagan said: "It's all a bit of a nightmare, but if you're at home to a team from a level below at this stage of the competition I don't think you can be anything other than happy.
"We like it playing at the Tameside Stadium. The groundsman, Nick Wild, has done a fantastic job in producing a slick surface which helps us move the ball."
Ashton United face a huge task at home to Salford City, but at least Paul Phillips and Steve Halford only have one player missing - defender Connor Roberts-Nurse who has a knee injury. Phillips is available again after completing a three-match ban.
Striker Ciaran Kilheeney needs a fitness test for Droylsden who face Vanarama North high-fliers Guiseley at the Butchers Arms. Ben Deegan is suspended.
Glossop North End also face Vanarama North opposition, in their case away to leaders Chorley. As a North West Counties League premier division club the Hillmen are very much the underdogs but manager Chris Willcock is eager for the challenge.
"We're all fit and ready for a great day and maybe a big upset. The lads can't wait for this one," he said.
In the only league game involving our local clubs, Mossley, who have hit a rich vein of form and gone fourth in the Evo-stik first division north, are home to Kendal whom they beat a couple of weeks ago.
Andy Keogh starts a three-match ban but Arron Hevingham and Tom Murray are both back in the squad.